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Yellow nail syndrome
Classification and external resources
ICD-10 L60.5
OMIM 153300
MedlinePlus 003247
eMedicine article/109403

Yellow nail syndrome (also known as "Primary lymphedema associated with yellow nails and pleural effusion"[1]:849) is a very rare medical syndrome that includes pleural effusions, lymphoedema and yellow dystrophic nails. Approximately 40% will also have bronchiectasis. It is also associated with chronic sinusitis and persistent coughing. It usually affects adults.[2 ][3]:665

Normal treatment for swelling and any respiratory problems is appropriate. Nutritional supplementation with Vitamin E in some studies has been shown to be effective in controlling nail changes.[2 ]

Restated, yellow nail syndrome is characterized by marked thickening and yellow to yellow-green discoloration of the nails often associated with systemic disease, most commonly lymphedema and compromised respiration.[1]:792[4]


  1. ^ a b James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.  
  2. ^ a b "Yellow nail syndrome. DermNet NZ". Retrieved 2008-03-19.  
  3. ^ Freedberg, et. al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0071380760.
  4. ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. pp. 1020. ISBN 1-4160-2999-0.  


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