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More info on Yttrium (90Y) tacatuzumab tetraxetan

Yttrium (90Y) tacatuzumab tetraxetan: Wikis

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Yttrium (90Y) tacatuzumab tetraxetan?
Monoclonal antibody
Source Human
Target α-fetoprotein
Identifiers
CAS number 500784-58-7
ATC code none
PubChem  ?
Chemical data
Formula C6470H9971N1712O2007S 4290Y
Mol. mass 145 kDa
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Yttrium (90Y) tacatuzumab tetraxetan (trade name AFP-Cide) is a humanized monoclonal antibody intended for the treatment of cancer.[1] The antibody itself, tacatuzumab, is conjugated with a chelator ("tetraxetan") for yttrium-90[2], a radioisotope which destroys the tumour cells.

"Tetraxetan" (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) chelating yttrium-90. The antibody is attached to one of the carboxyl groups as an amide.


References

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