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Zinc finger and BTB domain containing 17
Symbols ZBTB17; MIZ-1; ZNF151; pHZ-67
External IDs OMIM604084 MGI107410 HomoloGene2575 GeneCards: ZBTB17 Gene
RNA expression pattern
PBB GE ZBTB17 203602 s at tn.png
PBB GE ZBTB17 203601 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7709 22642
Ensembl ENSG00000116809 ENSMUSG00000006215
UniProt Q13105 Q6PAT9
RefSeq (mRNA) NM_003443 NM_009541
RefSeq (protein) NP_003434 NP_033567
Location (UCSC) Chr 1:
16.14 - 16.18 Mb
Chr 4:
140.72 - 140.74 Mb
PubMed search [1] [2]

Zinc finger and BTB domain-containing protein 17 is a protein that in humans is encoded by the ZBTB17 gene.[1]



ZBTB17 has been shown to interact with TOPBP1,[2] Host cell factor C1[3] and Myc.[4][5]


  1. ^ "Entrez Gene: ZBTB17 zinc finger and BTB domain containing 17".  
  2. ^ Herold, Steffi; Wanzel Michael, Beuger Vincent, Frohme Carsten, Beul Dorothee, Hillukkala Tomi, Syvaoja Juhani, Saluz Hans-Peter, Haenel Frank, Eilers Martin (Sep. 2002). "Negative regulation of the mammalian UV response by Myc through association with Miz-1". Mol. Cell (United States) 10 (3): 509–21. ISSN 1097-2765. PMID 12408820.  
  3. ^ Piluso, David; Bilan Patricia, Capone John P (Nov. 2002). "Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1". J. Biol. Chem. (United States) 277 (48): 46799–808. doi:10.1074/jbc.M206226200. ISSN 0021-9258. PMID 12244100.  
  4. ^ Staller, P; Peukert K, Kiermaier A, Seoane J, Lukas J, Karsunky H, Möröy T, Bartek J, Massagué J, Hänel F, Eilers M (Apr. 2001). "Repression of p15INK4b expression by Myc through association with Miz-1". Nat. Cell Biol. (England) 3 (4): 392–9. doi:10.1038/35070076. ISSN 1465-7392. PMID 11283613.  
  5. ^ Peukert, K; Staller P, Schneider A, Carmichael G, Hänel F, Eilers M (Sep. 1997). "An alternative pathway for gene regulation by Myc". EMBO J. (ENGLAND) 16 (18): 5672–86. doi:10.1093/emboj/16.18.5672. ISSN 0261-4189. PMID 9312026.  

Further reading

  • Lichter P, Bray P, Ried T, et al. (1992). "Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes.". Genomics 13 (4): 999–1007. doi:10.1016/0888-7543(92)90013-I. PMID 1505991.  
  • Bray P, Lichter P, Thiesen HJ, et al. (1991). "Characterization and mapping of human genes encoding zinc finger proteins.". Proc. Natl. Acad. Sci. U.S.A. 88 (21): 9563–7. doi:10.1073/pnas.88.21.9563. PMID 1946370.  
  • Tommerup N, Vissing H (1995). "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.". Genomics 27 (2): 259–64. doi:10.1006/geno.1995.1040. PMID 7557990.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Wu L, Wu H, Ma L, et al. (1997). "Miz1, a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA.". Mech. Dev. 65 (1-2): 3–17. doi:10.1016/S0925-4773(97)00032-4. PMID 9256341.  
  • Schneider A, Peukert K, Eilers M, Hänel F (1997). "Association of Myc with the zinc-finger protein Miz-1 defines a novel pathway for gene regulation by Myc.". Curr. Top. Microbiol. Immunol. 224: 137–46. PMID 9308237.  
  • Peukert K, Staller P, Schneider A, et al. (1997). "An alternative pathway for gene regulation by Myc.". Embo J. 16 (18): 5672–86. doi:10.1093/emboj/16.18.5672. PMID 9312026.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Sui D, Wilson JE (2000). "Interaction of insulin-like growth factor binding protein-4, Miz-1, leptin, lipocalin-type prostaglandin D synthase, and granulin precursor with the N-terminal half of type III hexokinase.". Arch. Biochem. Biophys. 382 (2): 262–74. doi:10.1006/abbi.2000.2019. PMID 11068878.  
  • Staller P, Peukert K, Kiermaier A, et al. (2001). "Repression of p15INK4b expression by Myc through association with Miz-1.". Nat. Cell Biol. 3 (4): 392–9. doi:10.1038/35070076. PMID 11283613.  
  • Ziegelbauer J, Shan B, Yager D, et al. (2001). "Transcription factor MIZ-1 is regulated via microtubule association.". Mol. Cell 8 (2): 339–49. doi:10.1016/S1097-2765(01)00313-6. PMID 11545736.  
  • Tussie-Luna MI, Michel B, Hakre S, Roy AL (2003). "The SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta /Siz2 is a transcriptional cofactor for TFII-I.". J. Biol. Chem. 277 (45): 43185–93. doi:10.1074/jbc.M207635200. PMID 12193603.  
  • Piluso D, Bilan P, Capone JP (2003). "Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1.". J. Biol. Chem. 277 (48): 46799–808. doi:10.1074/jbc.M206226200. PMID 12244100.  
  • Zhang H, Li Z, Viklund EK, Strömblad S (2002). "P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration.". J. Cell Biol. 158 (7): 1287–97. doi:10.1083/jcb.200207008. PMID 12356872.  
  • Herold S, Wanzel M, Beuger V, et al. (2002). "Negative regulation of the mammalian UV response by Myc through association with Miz-1.". Mol. Cell 10 (3): 509–21. doi:10.1016/S1097-2765(02)00633-0. PMID 12408820.  
  • Wu S, Cetinkaya C, Munoz-Alonso MJ, et al. (2003). "Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter.". Oncogene 22 (3): 351–60. doi:10.1038/sj.onc.1206145. PMID 12545156.  
  • Bowen H, Lapham A, Phillips E, et al. (2003). "Characterization of the murine Nramp1 promoter: requirements for transactivation by Miz-1.". J. Biol. Chem. 278 (38): 36017–26. doi:10.1074/jbc.M304301200. PMID 12840021.  
  • Sakurai T, Itoh K, Higashitsuji H, et al. (2004). "A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells.". J. Biol. Chem. 279 (15): 15505–14. doi:10.1074/jbc.M310437200. PMID 14739298.  
  • Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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