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ZBTB7A: Wikis


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Zinc finger and BTB domain containing 7A

PDB rendering based on 2if5.
Available structures
2if5, 2nn2
Symbols ZBTB7A; DKFZp547O146; FBI-1; FBI1; LRF; MGC99631; ZBTB7; pokemon
External IDs OMIM605878 MGI1335091 HomoloGene7820 GeneCards: ZBTB7A Gene
RNA expression pattern
PBB GE ZBTB7A 213299 at tn.png
PBB GE ZBTB7A 213303 x at tn.png
PBB GE ZBTB7A 219186 at tn.png
More reference expression data
Species Human Mouse
Entrez 51341 16969
Ensembl ENSG00000178951 ENSMUSG00000035011
UniProt O95365 Q3U372
RefSeq (mRNA) NM_015898 NM_010731
RefSeq (protein) NP_056982 NP_034861
Location (UCSC) Chr 19:
4 - 4.02 Mb
Chr 10:
80.55 - 80.55 Mb
PubMed search [1] [2]

Zinc finger and BTB domain-containing protein 7A is a protein that in humans is encoded by the ZBTB7A gene.[1][2][3]



ZBTB7A has been shown to interact with BCL6.[2]

See also


  1. ^ Morrison DJ, Pendergrast PS, Stavropoulos P, Colmenares SU, Kobayashi R, Hernandez N (Apr 1999). "FBI-1, a factor that binds to the HIV-1 inducer of short transcripts (IST), is a POZ domain protein". Nucleic Acids Res 27 (5): 1251–62. PMID 9973611.  
  2. ^ a b Davies JM, Hawe N, Kabarowski J, Huang QH, Zhu J, Brand NJ, Leprince D, Dhordain P, Cook M, Morriss-Kay G, Zelent A (Feb 1999). "Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene". Oncogene 18 (2): 365–75. doi:10.1038/sj.onc.1202332. PMID 9927193.  
  3. ^ "Entrez Gene: ZBTB7A zinc finger and BTB domain containing 7A".  

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Pendergrast PS, Wang C, Hernandez N, Huang S (2002). "FBI-1 can stimulate HIV-1 Tat activity and is targeted to a novel subnuclear domain that includes the Tat-P-TEFb-containing nuclear speckles.". Mol. Biol. Cell 13 (3): 915–29. doi:10.1091/mbc.01-08-0383. PMID 11907272.  
  • Lee DK, Suh D, Edenberg HJ, Hur MW (2002). "POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1.". J. Biol. Chem. 277 (30): 26761–8. doi:10.1074/jbc.M202078200. PMID 12004059.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Pessler F, Hernandez N (2003). "Flexible DNA binding of the BTB/POZ-domain protein FBI-1.". J. Biol. Chem. 278 (31): 29327–35. doi:10.1074/jbc.M302980200. PMID 12750370.  
  • Laudes M, Christodoulides C, Sewter C, et al. (2004). "Role of the POZ zinc finger transcription factor FBI-1 in human and murine adipogenesis.". J. Biol. Chem. 279 (12): 11711–8. doi:10.1074/jbc.M310240200. PMID 14701838.  
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.  
  • Liu CJ, Prazak L, Fajardo M, et al. (2004). "Leukemia/lymphoma-related factor, a POZ domain-containing transcriptional repressor, interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesis.". J. Biol. Chem. 279 (45): 47081–91. doi:10.1074/jbc.M405288200. PMID 15337766.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Maeda T, Hobbs RM, Merghoub T, et al. (2005). "Role of the proto-oncogene Pokémon in cellular transformation and ARF repression.". Nature 433 (7023): 278–85. doi:10.1038/nature03203. PMID 15662416.  
  • Lee DK, Kang JE, Park HJ, et al. (2005). "FBI-1 enhances transcription of the nuclear factor-kappaB (NF-kappaB)-responsive E-selectin gene by nuclear localization of the p65 subunit of NF-kappaB.". J. Biol. Chem. 280 (30): 27783–91. doi:10.1074/jbc.M504909200. PMID 15917220.  
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  
  • Roh HE, Lee MN, Jeon BN, et al. (2007). "Regulation of Pokémon 1 activity by sumoylation.". Cell. Physiol. Biochem. 20 (1-4): 167–80. doi:10.1159/000104164. PMID 17595526.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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