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ZBTB7B: Wikis


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From Wikipedia, the free encyclopedia

Zinc finger and BTB domain containing 7B
Symbols ZBTB7B; DKFZp686G01254; ZBTB15; ZFP67; c-Krox; hcKrox
External IDs OMIM607646 MGI102755 HomoloGene7605 GeneCards: ZBTB7B Gene
RNA expression pattern
PBB GE ZBTB7B 205853 at tn.png
More reference expression data
Species Human Mouse
Entrez 51043 22724
Ensembl ENSG00000160685 ENSMUSG00000028042
UniProt O15156 Q5BJ24
RefSeq (mRNA) NM_015872 XM_988936
RefSeq (protein) NP_056956 XP_994030
Location (UCSC) Chr 1:
153.24 - 153.26 Mb
Chr 3:
89.46 - 89.48 Mb
PubMed search [1] [2]

Zinc finger and BTB domain-containing protein 7B is a protein that in humans is encoded by the ZBTB7B gene.[1][2][3]

ZFP67 is an early growth response gene that encodes a zinc finger-containing transcription factor that binds to the promoter regions of type I collagen genes (e.g., COL1A1; MIM 120150) and has a role in development.[supplied by OMIM][3]


See also


  1. ^ Widom RL, Culic I, Lee JY, Korn JH (Dec 1997). "Cloning and characterization of hcKrox, a transcriptional regulator of extracellular matrix gene expression". Gene 198 (1-2): 407-20. PMID 9370309.  
  2. ^ Galera P, Musso M, Ducy P, Karsenty G (Oct 1994). "c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin". Proc Natl Acad Sci U S A 91 (20): 9372-6. PMID 7937772.  
  3. ^ a b "Entrez Gene: ZBTB7B zinc finger and BTB domain containing 7B".  

Further reading

  • Heegaard AM, Gehron Robey P, Vogel W, et al. (1998). "Functional characterization of the human biglycan 5'-flanking DNA and binding of the transcription factor c-Krox.". J. Bone Miner. Res. 12 (12): 2050–60. doi:10.1359/jbmr.1997.12.12.2050. PMID 9421237.  
  • Ghayor C, Herrouin JF, Chadjichristos C, et al. (2000). "Regulation of human COL2A1 gene expression in chondrocytes. Identification of C-Krox-responsive elements and modulation by phenotype alteration.". J. Biol. Chem. 275 (35): 27421–38. doi:10.1074/jbc.M002139200. PMID 10856292.  
  • Widom RL, Lee JY, Joseph C, et al. (2002). "The hcKrox gene family regulates multiple extracellular matrix genes.". Matrix Biol. 20 (7): 451–62. doi:10.1016/S0945-053X(01)00167-6. PMID 11691585.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.  
  • Kypriotou M, Beauchef G, Chadjichristos C, et al. (2007). "Human collagen Krox up-regulates type I collagen expression in normal and scleroderma fibroblasts through interaction with Sp1 and Sp3 transcription factors.". J. Biol. Chem. 282 (44): 32000–14. doi:10.1074/jbc.M705197200. PMID 17698844.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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