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From Wikipedia, the free encyclopedia

AT-binding transcription factor 1

PDB rendering based on 2da1.
Available structures
2da1, 2da2, 2da3
Symbols ATBF1; ATBT; ZFHX3
External IDs OMIM104155 MGI99948 HomoloGene21366 GeneCards: ATBF1 Gene
RNA expression pattern
PBB GE ATBF1 208033 s at tn.png
More reference expression data
Species Human Mouse
Entrez 463 11906
Ensembl ENSG00000140836 ENSMUSG00000038872
UniProt Q15911 Q5DTG5
RefSeq (mRNA) NM_006885 NM_007496
RefSeq (protein) NP_008816 NP_031522
Location (UCSC) Chr 16:
71.38 - 71.64 Mb
Chr 8:
111.6 - 111.85 Mb
PubMed search [1] [2]

Zinc finger homeobox protein 3 is a protein that in humans is encoded by the ZFHX3 gene.[1][2][3]


  1. ^ Morinaga T, Yasuda H, Hashimoto T, Higashio K, Tamaoki T (Dec 1991). "A human alpha-fetoprotein enhancer-binding protein, ATBF1, contains four homeodomains and seventeen zinc fingers". Mol Cell Biol 11 (12): 6041-9. PMID 1719379.  
  2. ^ Miura Y, Tam T, Ido A, Morinaga T, Miki T, Hashimoto T, Tamaoki T (Dec 1995). "Cloning and characterization of an ATBF1 isoform that expresses in a neuronal differentiation-dependent manner". J Biol Chem 270 (45): 26840-8. PMID 7592926.  
  3. ^ "Entrez Gene: ATBF1 AT-binding transcription factor 1".  

Further reading

  • Yamada K, Miura Y, Scheidl T, et al. (1996). "Assignment of the human ATBF1 transcription factor gene to chromosome 16q22.3-q23.1.". Genomics 29 (2): 552–3. doi:10.1006/geno.1995.9967. PMID 8666409.  
  • Bedford MT, Chan DC, Leder P (1997). "FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands.". EMBO J. 16 (9): 2376–83. doi:10.1093/emboj/16.9.2376. PMID 9171351.  
  • Kaspar P, Dvoráková M, Králová J, et al. (1999). "Myb-interacting protein, ATBF1, represses transcriptional activity of Myb oncoprotein.". J. Biol. Chem. 274 (20): 14422–8. doi:10.1074/jbc.274.20.14422. PMID 10318867.  
  • Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.". Genomics 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.  
  • Kaushik N, Malaspina A, de Belleroche J (2000). "Characterization of trinucleotide- and tandem repeat-containing transcripts obtained from human spinal cord cDNA library by high-density filter hybridization.". DNA Cell Biol. 19 (5): 265–73. doi:10.1089/10445490050021177. PMID 10855793.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Iida M, Imura J, Furuichi T, et al. (2004). "Alteration of the AT motif binding factor-1 expression in alpha-fetoprotein producing gastric cancer: is it an event for differentiation and proliferation of the tumors?". Oncol. Rep. 11 (1): 3–7. PMID 14654895.  
  • Nojiri S, Joh T, Miura Y, et al. (2004). "ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3.". Biochem. Biophys. Res. Commun. 314 (1): 97–103. doi:10.1016/j.bbrc.2003.12.054. PMID 14715251.  
  • Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16.". Nature 432 (7020): 988–94. doi:10.1038/nature03187. PMID 15616553.  
  • Zhang Z, Yamashita H, Toyama T, et al. (2005). "ATBF1-a messenger RNA expression is correlated with better prognosis in breast cancer.". Clin. Cancer Res. 11 (1): 193–8. PMID 15671546.  
  • Sun X, Frierson HF, Chen C, et al. (2005). "Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer.". Nat. Genet. 37 (4): 407–12. doi:10.1038/ng1528. PMID 15750593.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Xu J, Sauvageot J, Ewing CM, et al. (2006). "Germline ATBF1 mutations and prostate cancer risk.". Prostate 66 (10): 1082–5. doi:10.1002/pros.20430. PMID 16637072.  
  • Sun X, Zhou Y, Otto KB, et al. (2007). "Infrequent mutation of ATBF1 in human breast cancer.". J. Cancer Res. Clin. Oncol. 133 (2): 103–5. doi:10.1007/s00432-006-0148-y. PMID 16932943.  
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  
  • Mori Y, Kataoka H, Miura Y, et al. (2007). "Subcellular localization of ATBF1 regulates MUC5AC transcription in gastric cancer.". Int. J. Cancer 121 (2): 241–7. doi:10.1002/ijc.22654. PMID 17330845.  
  • Cho YG, Song JH, Kim CJ, et al. (2007). "Genetic alterations of the ATBF1 gene in gastric cancer.". Clin. Cancer Res. 13 (15 Pt 1): 4355–9. doi:10.1158/1078-0432.CCR-07-0619. PMID 17671116.  

External links



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