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Zic family member 1 (odd-paired homolog, Drosophila)
Symbols ZIC1; ZIC; ZNF201
External IDs OMIM600470 MGI106683 HomoloGene2562 GeneCards: ZIC1 Gene
RNA expression pattern
PBB GE ZIC1 206373 at tn.png
More reference expression data
Species Human Mouse
Entrez 7545 22771
Ensembl ENSG00000152977 ENSMUSG00000032368
UniProt Q15915 Q3TWA9
RefSeq (mRNA) NM_003412 XM_973507
RefSeq (protein) NP_003403 XP_978601
Location (UCSC) Chr 3:
148.61 - 148.62 Mb
Chr 9:
91.16 - 91.16 Mb
PubMed search [1] [2]

Zinc finger protein ZIC 1 is a protein that in humans is encoded by the ZIC1 gene.[1][2]

This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene.[2]


ZIC1 has been shown to interact with GLI1[3] and GLI3.[3]


  1. ^ Yokota N, Aruga J, Takai S, Yamada K, Hamazaki M, Iwase T, Sugimura H, Mikoshiba K (Feb 1996). "Predominant expression of human zic in cerebellar granule cell lineage and medulloblastoma". Cancer Res 56 (2): 377–83. PMID 8542595.  
  2. ^ a b "Entrez Gene: ZIC1 Zic family member 1 (odd-paired homolog, Drosophila)".  
  3. ^ a b Koyabu, Y; Nakata K, Mizugishi K, Aruga J, Mikoshiba K (Mar. 2001). "Physical and functional interactions between Zic and Gli proteins". J. Biol. Chem. (United States) 276 (10): 6889–92. doi:10.1074/jbc.C000773200. ISSN 0021-9258. PMID 11238441.  

Further reading

  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.  
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.  
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMID 10737800.  
  • Michiels EM, Oussoren E, Van Groenigen M, et al. (2000). "Genes differentially expressed in medulloblastoma and fetal brain.". Physiol. Genomics 1 (2): 83–91. PMID 11015565.  
  • Salero E, Pérez-Sen R, Aruga J, et al. (2001). "Transcription factors Zic1 and Zic2 bind and transactivate the apolipoprotein E gene promoter.". J. Biol. Chem. 276 (3): 1881–8. doi:10.1074/jbc.M007008200. PMID 11038359.  
  • Koyabu Y, Nakata K, Mizugishi K, et al. (2001). "Physical and functional interactions between Zic and Gli proteins.". J. Biol. Chem. 276 (10): 6889–92. doi:10.1074/jbc.C000773200. PMID 11238441.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Bagutti C, Forro G, Ferralli J, et al. (2004). "The intracellular domain of teneurin-2 has a nuclear function and represses zic-1-mediated transcription.". J. Cell. Sci. 116 (Pt 14): 2957–66. doi:10.1242/jcs.00603. PMID 12783990.  
  • Bennett CL, Parisi MA, Eckert ML, et al. (2004). "Joubert syndrome: a haplotype segregation strategy and exclusion of the zinc finger protein of cerebellum 1 (ZIC1) gene.". Am. J. Med. Genet. A 125 (2): 117–24; discussion 117. doi:10.1002/ajmg.a.20438. PMID 14981711.  
  • Grinberg I, Northrup H, Ardinger H, et al. (2004). "Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved in Dandy-Walker malformation.". Nat. Genet. 36 (10): 1053–5. doi:10.1038/ng1420. PMID 15338008.  
  • Pourebrahim R, Van Dam K, Bauters M, et al. (2007). "ZIC1 gene expression is controlled by DNA and histone methylation in mesenchymal proliferations.". FEBS Lett. 581 (26): 5122–6. doi:10.1016/j.febslet.2007.09.061. PMID 17936758.  


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