The Full Wiki

More info on ZK-93426

ZK-93426: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

ZK-93426
Identifiers
CAS number 89592-45-0
PubChem 115210
SMILES
Properties
Molecular formula C18H20N2O3
Molar mass 314.336 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

ZK-93426 (ethyl-5-isopropoxy-4-methyl-beta-carboline-3-carboxylate) is a drug from the beta-carboline family. It acts as a weak partial inverse agonist of benzodiazepine receptors,[1] meaning that it causes the opposite effects to the benzodiazepine class of drugs and has anxiogenic properties,[2] although unlike most benzodiazepine antagonists it is not a convulsant and actually has weak anticonvulsant effects.[3] In human tests it produced alertness, restlessness and feelings of apprehension, and reversed the effect of the benzodiazepine lormetazepam.[4][5] It was also shown to produce nootropic effects[6][7] and increased release of acetylcholine.[8][9]

References

  1. ^ Camerman A, Mastropaolo D, Hempel A, Camerman N. Ethyl 5-isopropoxy-4-methyl-beta-carboline-3-carboxylate: structural determinants of benzodiazepine-receptor antagonism. Acta Crystallographica Section C. 2005 Apr;61(Pt 4):o265-6. PMID 15805647
  2. ^ File SE, Pellow S, Jensen LH. Actions of the beta-carboline ZK 93426 in an animal test of anxiety and the holeboard: interactions with Ro 15-1788. Journal of Neural Transmission. 1986;65(2):103-14. PMID 3009709
  3. ^ Jensen LH, Petersen EN, Braestrup C, Honoré T, Kehr W, Stephens DN, Schneider H, Seidelmann D, Schmiechen R. Evaluation of the beta-carboline ZK 93 426 as a benzodiazepine receptor antagonist. Psychopharmacology (Berlin). 1984;83(3):249-56. PMID 6089247
  4. ^ Dorow R, Duka T, Höller L, Sauerbrey N. Clinical perspectives of beta-carbolines from first studies in humans. Brain Research Bulletin. 1987 Sep;19(3):319-26. PMID 2890423
  5. ^ Duka T, Goerke D, Dorow R, Höller L, Fichte K. Human studies on the benzodiazepine receptor antagonist beta-carboline ZK 93 426: antagonism of lormetazepam's psychotropic effects. Psychopharmacology (Berlin). 1988;95(4):463-71. PMID 2905500
  6. ^ Duka T, Edelmann V, Schütt B, Dorow R. Beta-carbolines as tools in memory research: human data with the beta-carboline ZK 93426. Psychopharmacol Series. 1988;6:246-60. PMID 3064085
  7. ^ Duka T, Ott H, Rohloff A, Voet B. The effects of a benzodiazepine receptor antagonist beta-carboline ZK-93426 on scopolamine-induced impairment on attention, memory and psychomotor skills. Psychopharmacology (Berlin). 1996 Feb;123(4):361-73. PMID 8867876
  8. ^ Moore H, Sarter M, Bruno JP. Age-dependent modulation of in vivo cortical acetylcholine release by benzodiazepine receptor ligands. Brain Research. 1992 Nov 20;596(1-2):17-29. PMID 1334777
  9. ^ Moore H, Sarter M, Bruno JP. Bidirectional modulation of stimulated cortical acetylcholine release by benzodiazepine receptor ligands. Brain Research. 1993 Nov 12;627(2):267-74. PMID 8298971
Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message