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Zinc finger protein 10
Identifiers
Symbols ZNF10; KOX1
External IDs OMIM194538 GeneCards: ZNF10 Gene
RNA expression pattern
PBB GE ZNF10 216350 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7556 n/a
Ensembl ENSG00000090612 n/a
UniProt P21506 n/a
RefSeq (mRNA) NM_015394 n/a
RefSeq (protein) NP_056209 n/a
Location (UCSC) Chr 12:
132.23 - 132.24 Mb
n/a
PubMed search [1] n/a

Zinc finger protein 10 is a protein that in humans is encoded by the ZNF10 gene.[1][2][3]

The protein encoded by this gene contains a C2H2 zinc finger, and has been shown to function as a transcriptional repressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptional repression activity. RING finger containing protein TIF1 was reported to interact with the KRAB domain, and may serve as a mediator for the repression activity of this protein.[3]

Contents

Interactions

ZNF10 has been shown to interact with TRIM28.[4][5]

References

  1. ^ Abrink M, Aveskogh M, Hellman L (Mar 1995). "Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937". DNA Cell Biol 14 (2): 125–36. PMID 7865130.  
  2. ^ Rousseau-Merck MF, Hillion J, Jonveaux P, Couillin P, Seite P, Thiesen HJ, Berger R (Jan 1994). "Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19". Hum Genet 92 (6): 583–7. PMID 8262519.  
  3. ^ a b "Entrez Gene: ZNF10 zinc finger protein 10". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7556.  
  4. ^ Moosmann, P; Georgiev O, Le Douarin B, Bourquin J P, Schaffner W (Dec. 1996). "Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1". Nucleic Acids Res. (ENGLAND) 24 (24): 4859–67. ISSN 0305-1048. PMID 9016654.  
  5. ^ Peng, H; Begg G E, Harper S L, Friedman J R, Speicher D W, Rauscher F J (Jun. 2000). "Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain". J. Biol. Chem. (UNITED STATES) 275 (24): 18000–10. doi:10.1074/jbc.M001499200. ISSN 0021-9258. PMID 10748030.  

Further reading

  • Huebner K, Druck T, Croce CM, Thiesen HJ (1991). "Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering.". Am. J. Hum. Genet. 48 (4): 726–40. PMID 2014798.  
  • Thiesen HJ (1991). "Multiple genes encoding zinc finger domains are expressed in human T cells.". New Biol. 2 (4): 363–74. PMID 2288909.  
  • Vissing H, Meyer WK, Aagaard L, et al. (1995). "Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins.". FEBS Lett. 369 (2-3): 153–7. doi:10.1016/0014-5793(95)00728-R. PMID 7649249.  
  • Moosmann P, Georgiev O, Le Douarin B, et al. (1997). "Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1.". Nucleic Acids Res. 24 (24): 4859–67. doi:10.1093/nar/24.24.4859. PMID 9016654.  
  • Moosmann P, Georgiev O, Thiesen HJ, et al. (1998). "Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a Krüppel-type zinc finger factor.". Biol. Chem. 378 (7): 669–77. PMID 9278146.  
  • Peng H, Begg GE, Harper SL, et al. (2000). "Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain.". J. Biol. Chem. 275 (24): 18000–10. doi:10.1074/jbc.M001499200. PMID 10748030.  
  • Lorenz P, Koczan D, Thiesen HJ (2001). "Transcriptional repression mediated by the KRAB domain of the human C2H2 zinc finger protein Kox1/ZNF10 does not require histone deacetylation.". Biol. Chem. 382 (4): 637–44. doi:10.1515/BC.2001.075. PMID 11405226.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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