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Zinc finger protein 217
Identifiers
Symbols ZNF217; ZABC1
External IDs OMIM602967 MGI2685408 HomoloGene4757 GeneCards: ZNF217 Gene
RNA expression pattern
PBB GE ZNF217 203739 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7764 228913
Ensembl ENSG00000171940 ENSMUSG00000052056
UniProt O75362 n/a
RefSeq (mRNA) NM_006526 XM_985378
RefSeq (protein) NP_006517 XP_990472
Location (UCSC) Chr 20:
51.62 - 51.63 Mb
Chr 2:
169.8 - 169.82 Mb
PubMed search [1] [2]

Zinc finger protein 217, also known as ZNF217, is a protein which in humans is encoded by the ZNF217 gene.[1][2]

Contents

Function

ZNF217 can attenuate apoptotic signals resulting from telomere dysfunction and may promote neoplastic transformation and later stages of malignancy.[3]

See also

References

  1. ^ Collins C, Rommens JM, Kowbel D, Godfrey T, Tanner M, Hwang SI, Polikoff D, Nonet G, Cochran J, Myambo K, Jay KE, Froula J, Cloutier T, Kuo WL, Yaswen P, Dairkee S, Giovanola J, Hutchinson GB, Isola J, Kallioniemi OP, Palazzolo M, Martin C, Ericsson C, Pinkel D, Albertson D, Li WB, Gray JW (July 1998). "Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8703–8. PMID 9671742.  
  2. ^ "Entrez Gene: ZNF217 zinc finger protein 217". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7764.  
  3. ^ Huang G, Krig S, Kowbel D, Xu H, Hyun B, Volik S, Feuerstein B, Mills GB, Stokoe D, Yaswen P, Collins C (November 2005). "ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction". Hum. Mol. Genet. 14 (21): 3219–25. doi:10.1093/hmg/ddi352. PMID 16203743.  

Further reading

  • Quinlan KG, Verger A, Yaswen P, Crossley M (2007). "Amplification of zinc finger gene 217 (ZNF217) and cancer: when good fingers go bad.". Biochim. Biophys. Acta 1775 (2): 333–40. doi:10.1016/j.bbcan.2007.05.001. PMID 17572303.  
  • Kallioniemi A, Kallioniemi OP, Piper J, et al. (1994). "Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization.". Proc. Natl. Acad. Sci. U.S.A. 91 (6): 2156–60. doi:10.1073/pnas.91.6.2156. PMID 8134364.  
  • Collins C, Rommens JM, Kowbel D, et al. (1998). "Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma.". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8703–8. doi:10.1073/pnas.95.15.8703. PMID 9671742.  
  • Nonet GH, Stampfer MR, Chin K, et al. (2001). "The ZNF217 gene amplified in breast cancers promotes immortalization of human mammary epithelial cells.". Cancer Res. 61 (4): 1250–4. PMID 11245413.  
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Hakimi MA, Dong Y, Lane WS, et al. (2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.". J. Biol. Chem. 278 (9): 7234–9. doi:10.1074/jbc.M208992200. PMID 12493763.  
  • Weiss MM, Snijders AM, Kuipers EJ, et al. (2003). "Determination of amplicon boundaries at 20q13.2 in tissue samples of human gastric adenocarcinomas by high-resolution microarray comparative genomic hybridization.". J. Pathol. 200 (3): 320–6. doi:10.1002/path.1359. PMID 12845628.  
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Shimada M, Imura J, Kozaki T, et al. (2005). "Detection of Her2/neu, c-MYC and ZNF217 gene amplification during breast cancer progression using fluorescence in situ hybridization.". Oncol. Rep. 13 (4): 633–41. PMID 15756435.  
  • Huang G, Krig S, Kowbel D, et al. (2006). "ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction.". Hum. Mol. Genet. 14 (21): 3219–25. doi:10.1093/hmg/ddi352. PMID 16203743.  
  • Quinlan KG, Nardini M, Verger A, et al. (2007). "Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins.". Mol. Cell. Biol. 26 (21): 8159–72. doi:10.1128/MCB.00680-06. PMID 16940172.  
  • Cowger JJ, Zhao Q, Isovic M, Torchia J (2007). "Biochemical characterization of the zinc-finger protein 217 transcriptional repressor complex: identification of a ZNF217 consensus recognition sequence.". Oncogene 26 (23): 3378–86. doi:10.1038/sj.onc.1210126. PMID 17130829.  

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