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Zinc finger protein 238
Symbols ZNF238; C2H2-171; RP58; TAZ-1; ZBTB18
External IDs OMIM608433 MGI1353609 HomoloGene21276 GeneCards: ZNF238 Gene
RNA expression pattern
PBB GE ZNF238 212774 at tn.png
PBB GE ZNF238 207164 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10472 30928
Ensembl ENSG00000179456 ENSMUSG00000063659
UniProt Q99592 Q3UHU9
RefSeq (mRNA) NM_006352 NM_001012330
RefSeq (protein) NP_006343 NP_001012330
Location (UCSC) Chr 1:
242.28 - 242.29 Mb
Chr 1:
179.28 - 179.29 Mb
PubMed search [1] [2]

Zinc finger protein 238 is a protein that in humans is encoded by the ZNF238 gene.[1][2][3]

C2H2-type zinc finger proteins, such as ZNF238, act on the molecular level as transcriptional activators or repressors and are involved in chromatin assembly.[supplied by OMIM][3]



ZNF238 has been shown to interact with DNMT3A.[4]


  1. ^ Becker KG, Lee IJ, Nagle JW, Canning RD, Gado AM, Torres R, Polymeropoulos MH, Massa PT, Biddison WE, Drew PD (Jun 1998). "C2H2-171: a novel human cDNA representing a developmentally regulated POZ domain/zinc finger protein preferentially expressed in brain". Int J Dev Neurosci 15 (7): 891–9. PMID 9568537.  
  2. ^ Aoki K, Ishida R, Kasai M (Feb 1997). "Isolation and characterization of a cDNA encoding a Translin-like protein, TRAX". FEBS Lett 401 (2-3): 109–12. PMID 9013868.  
  3. ^ a b "Entrez Gene: ZNF238 zinc finger protein 238".  
  4. ^ Fuks, F; Burgers W A, Godin N, Kasai M, Kouzarides T (May. 2001). "Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription". EMBO J. (England) 20 (10): 2536–44. doi:10.1093/emboj/20.10.2536. ISSN 0261-4189. PMID 11350943.  

Further reading

  • Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3–174. PMID 7566098.  
  • Becker KG, Nagle JW, Canning RD, et al. (1995). "Rapid isolation and characterization of 118 novel C2H2-type zinc finger cDNAs expressed in human brain.". Hum. Mol. Genet. 4 (4): 685–91. doi:10.1093/hmg/4.4.685. PMID 7633419.  
  • Aoki K, Meng G, Suzuki K, et al. (1998). "RP58 associates with condensed chromatin and mediates a sequence-specific transcriptional repression.". J. Biol. Chem. 273 (41): 26698–704. doi:10.1074/jbc.273.41.26698. PMID 9756912.  
  • Ahmad KF, Engel CK, Privé GG (1998). "Crystal structure of the BTB domain from PLZF.". Proc. Natl. Acad. Sci. U.S.A. 95 (21): 12123–8. doi:10.1073/pnas.95.21.12123. PMID 9770450.  
  • Meng G, Inazawa J, Ishida R, et al. (2000). "Structural analysis of the gene encoding RP58, a sequence-specific transrepressor associated with heterochromatin.". Gene 242 (1-2): 59–64. doi:10.1016/S0378-1119(99)00477-1. PMID 10721697.  
  • Fuks F, Burgers WA, Godin N, et al. (2001). "Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription.". Embo J. 20 (10): 2536–44. doi:10.1093/emboj/20.10.2536. PMID 11350943.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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