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Zinc finger protein 346
Symbols ZNF346; DKFZp547M223; JAZ; Zfp346
External IDs OMIM605308 MGI1349417 HomoloGene8073 GeneCards: ZNF346 Gene
Species Human Mouse
Entrez 23567 26919
Ensembl ENSG00000113761 ENSMUSG00000021481
UniProt Q9UL40 Q8CEE9
RefSeq (mRNA) NM_012279 NM_012017
RefSeq (protein) NP_036411 NP_036147
Location (UCSC) Chr 5:
176.38 - 176.44 Mb
Chr 13:
55.11 - 55.14 Mb
PubMed search [1] [2]

Zinc finger protein 346 is a protein that in humans is encoded by the ZNF346 gene.[1][2]

The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival.[2]


  1. ^ Yang M, May WS, Ito T (Nov 1999). "JAZ requires the double-stranded RNA-binding zinc finger motifs for nuclear localization". J Biol Chem 274 (39): 27399-406. PMID 10488071.  
  2. ^ a b "Entrez Gene: ZNF346 zinc finger protein 346".  

Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMID 11076863.  
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Chen T, Brownawell AM, Macara IG (2004). "Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5.". Mol. Cell. Biol. 24 (15): 6608–19. doi:10.1128/MCB.24.15.6608-6619.2004. PMID 15254228.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.  
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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