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Zinc finger protein 350
Identifiers
Symbols ZNF350; ZBRK1; ZFQR
External IDs OMIM605422 GeneCards: ZNF350 Gene
RNA expression pattern
PBB GE ZNF350 219266 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 59348 n/a
Ensembl ENSG00000171032 n/a
UniProt Q9GZX5 n/a
RefSeq (mRNA) NM_021632 n/a
RefSeq (protein) NP_067645 n/a
Location (UCSC) Chr 19:
57.16 - 57.18 Mb
n/a
PubMed search [1] n/a

Zinc finger protein 350 is a protein that in humans is encoded by the ZNF350 gene.[1][2][3]

Contents

Interactions

ZNF350 has been shown to interact with BRCA1.[1]

See also

References

  1. ^ a b Zheng L, Pan H, Li S, Flesken-Nikitin A, Chen PL, Boyer TG, Lee WH (Nov 2000). "Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1". Mol Cell 6 (4): 757–68. PMID 11090615.  
  2. ^ Ran Q, Wadhwa R, Bischof O, Venable S, Smith JR, Pereira-Smith OM (Feb 2001). "Characterization of a novel zinc finger gene with increased expression in nondividing normal human cells". Exp Cell Res 263 (1): 156–62. doi:10.1006/excr.2000.5068. PMID 11161714.  
  3. ^ "Entrez Gene: ZNF350 zinc finger protein 350". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=59348.  

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Rutter JL, Smith AM, Dávila MR, et al. (2004). "Mutational analysis of the BRCA1-interacting genes ZNF350/ZBRK1 and BRIP1/BACH1 among BRCA1 and BRCA2-negative probands from breast-ovarian cancer families and among early-onset breast cancer cases and reference individuals.". Hum. Mutat. 22 (2): 121–8. doi:10.1002/humu.10238. PMID 12872252.  
  • Yun J, Lee WH (2003). "Degradation of transcription repressor ZBRK1 through the ubiquitin-proteasome pathway relieves repression of Gadd45a upon DNA damage.". Mol. Cell. Biol. 23 (20): 7305–14. doi:10.1128/MCB.23.20.7305-7314.2003. PMID 14517299.  
  • Tan W, Zheng L, Lee WH, Boyer TG (2004). "Functional dissection of transcription factor ZBRK1 reveals zinc fingers with dual roles in DNA-binding and BRCA1-dependent transcriptional repression.". J. Biol. Chem. 279 (8): 6576–87. doi:10.1074/jbc.M312270200. PMID 14660588.  
  • Surpili MJ, Delben TM, Kobarg J (2004). "Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1.". Biochemistry 42 (51): 15369–76. doi:10.1021/bi034575v. PMID 14690447.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Li H, Seth A (2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein.". Oncogene 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. PMID 14755250.  
  • Tan W, Kim S, Boyer TG (2005). "Tetrameric oligomerization mediates transcriptional repression by the BRCA1-dependent Kruppel-associated box-zinc finger protein ZBRK1.". J. Biol. Chem. 279 (53): 55153–60. doi:10.1074/jbc.M410926200. PMID 15496401.  
  • Liao G, Huang J, Fixman ED, Hayward SD (2005). "The Epstein-Barr virus replication protein BBLF2/3 provides an origin-tethering function through interaction with the zinc finger DNA binding protein ZBRK1 and the KAP-1 corepressor.". J. Virol. 79 (1): 245–56. doi:10.1128/JVI.79.1.245-256.2005. PMID 15596820.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Bulliard Y, Wiznerowicz M, Barde I, Trono D (2007). "KRAB can repress lentivirus proviral transcription independently of integration site.". J. Biol. Chem. 281 (47): 35742–6. doi:10.1074/jbc.M602843200. PMID 16997916.  
  • Desjardins S, Belleau P, Labrie Y, et al. (2007). "Genetic variants and haplotype analyses of the ZBRK1/ZNF350 gene in high-risk non BRCA1/2 French Canadian breast and ovarian cancer families.". Int. J. Cancer 122 (1): 108–16. doi:10.1002/ijc.23058. PMID 17764113.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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