The Full Wiki

ZNF350: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

Zinc finger protein 350
Symbols ZNF350; ZBRK1; ZFQR
External IDs OMIM605422 GeneCards: ZNF350 Gene
RNA expression pattern
PBB GE ZNF350 219266 at tn.png
More reference expression data
Species Human Mouse
Entrez 59348 n/a
Ensembl ENSG00000171032 n/a
UniProt Q9GZX5 n/a
RefSeq (mRNA) NM_021632 n/a
RefSeq (protein) NP_067645 n/a
Location (UCSC) Chr 19:
57.16 - 57.18 Mb
PubMed search [1] n/a

Zinc finger protein 350 is a protein that in humans is encoded by the ZNF350 gene.[1][2][3]



ZNF350 has been shown to interact with BRCA1.[1]

See also


  1. ^ a b Zheng L, Pan H, Li S, Flesken-Nikitin A, Chen PL, Boyer TG, Lee WH (Nov 2000). "Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1". Mol Cell 6 (4): 757–68. PMID 11090615.  
  2. ^ Ran Q, Wadhwa R, Bischof O, Venable S, Smith JR, Pereira-Smith OM (Feb 2001). "Characterization of a novel zinc finger gene with increased expression in nondividing normal human cells". Exp Cell Res 263 (1): 156–62. doi:10.1006/excr.2000.5068. PMID 11161714.  
  3. ^ "Entrez Gene: ZNF350 zinc finger protein 350".  

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Rutter JL, Smith AM, Dávila MR, et al. (2004). "Mutational analysis of the BRCA1-interacting genes ZNF350/ZBRK1 and BRIP1/BACH1 among BRCA1 and BRCA2-negative probands from breast-ovarian cancer families and among early-onset breast cancer cases and reference individuals.". Hum. Mutat. 22 (2): 121–8. doi:10.1002/humu.10238. PMID 12872252.  
  • Yun J, Lee WH (2003). "Degradation of transcription repressor ZBRK1 through the ubiquitin-proteasome pathway relieves repression of Gadd45a upon DNA damage.". Mol. Cell. Biol. 23 (20): 7305–14. doi:10.1128/MCB.23.20.7305-7314.2003. PMID 14517299.  
  • Tan W, Zheng L, Lee WH, Boyer TG (2004). "Functional dissection of transcription factor ZBRK1 reveals zinc fingers with dual roles in DNA-binding and BRCA1-dependent transcriptional repression.". J. Biol. Chem. 279 (8): 6576–87. doi:10.1074/jbc.M312270200. PMID 14660588.  
  • Surpili MJ, Delben TM, Kobarg J (2004). "Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1.". Biochemistry 42 (51): 15369–76. doi:10.1021/bi034575v. PMID 14690447.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Li H, Seth A (2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein.". Oncogene 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. PMID 14755250.  
  • Tan W, Kim S, Boyer TG (2005). "Tetrameric oligomerization mediates transcriptional repression by the BRCA1-dependent Kruppel-associated box-zinc finger protein ZBRK1.". J. Biol. Chem. 279 (53): 55153–60. doi:10.1074/jbc.M410926200. PMID 15496401.  
  • Liao G, Huang J, Fixman ED, Hayward SD (2005). "The Epstein-Barr virus replication protein BBLF2/3 provides an origin-tethering function through interaction with the zinc finger DNA binding protein ZBRK1 and the KAP-1 corepressor.". J. Virol. 79 (1): 245–56. doi:10.1128/JVI.79.1.245-256.2005. PMID 15596820.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Bulliard Y, Wiznerowicz M, Barde I, Trono D (2007). "KRAB can repress lentivirus proviral transcription independently of integration site.". J. Biol. Chem. 281 (47): 35742–6. doi:10.1074/jbc.M602843200. PMID 16997916.  
  • Desjardins S, Belleau P, Labrie Y, et al. (2007). "Genetic variants and haplotype analyses of the ZBRK1/ZNF350 gene in high-risk non BRCA1/2 French Canadian breast and ovarian cancer families.". Int. J. Cancer 122 (1): 108–16. doi:10.1002/ijc.23058. PMID 17764113.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



Got something to say? Make a comment.
Your name
Your email address