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Zinc finger protein 41
Identifiers
Symbols ZNF41; MGC8941; MRX89
External IDs OMIM314995 HomoloGene56023 GeneCards: ZNF41 Gene
RNA expression pattern
PBB GE ZNF41 214904 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7592 n/a
Ensembl ENSG00000147124 n/a
UniProt P51814 n/a
RefSeq (mRNA) NM_007130 n/a
RefSeq (protein) NP_009061 n/a
Location (UCSC) Chr X:
47.19 - 47.23 Mb
n/a
PubMed search [1] n/a

Zinc finger protein 41 is a protein that in humans is encoded by the ZNF41 gene.[1][2]

This gene product is a likely zinc finger family transcription factor. It contains KRAB-A and KRAB-B domains that act as transcriptional repressors in related proteins, and multiple zinc finger DNA binding motifs and finger linking regions characteristic of the Kruppel family. This gene is part of a gene cluster on chromosome Xp11.23. Several alternatively spliced transcript variants have been described, however, the full-length nature of only some of them is known.[2]

References

  1. ^ Franze A, Archidiacono N, Rocchi M, Marino M, Grimaldi G (Jul 1991). "Isolation and expression analysis of a human zinc finger gene (ZNF41) located on the short arm of the X chromosome". Genomics 9 (4): 728-36. PMID 2037297.  
  2. ^ a b "Entrez Gene: ZNF41 zinc finger protein 41". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7592.  

Further reading

  • Rosati M, Marino M, Franzè A, et al. (1991). "Members of the zinc finger protein gene family sharing a conserved N-terminal module.". Nucleic Acids Res. 19 (20): 5661–7. doi:10.1093/nar/19.20.5661. PMID 1945843.  
  • Knight JC, Grimaldi G, Thiesen HJ, et al. (1994). "Clustered organization of Krüppel zinc-finger genes at Xp11.23, flanking a translocation breakpoint at OATL1: a physical map with locus assignments for ZNF21, ZNF41, ZNF81, and ELK1.". Genomics 21 (1): 180–7. doi:10.1006/geno.1994.1240. PMID 8088786.  
  • Rosati M, Franzé A, Matarazzo MR, Grimaldi G (1999). "Coding region intron/exon organization, alternative splicing, and X-chromosome inactivation of the KRAB/FPB-domain-containing human zinc finger gene ZNF41.". Cytogenet. Cell Genet. 85 (3-4): 291–6. doi:10.1159/000015315. PMID 10449920.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Shoichet SA, Hoffmann K, Menzel C, et al. (2004). "Mutations in the ZNF41 gene are associated with cognitive deficits: identification of a new candidate for X-linked mental retardation.". Am. J. Hum. Genet. 73 (6): 1341–54. doi:10.1086/380309. PMID 14628291.  
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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