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Zinc finger protein 74
Symbols ZNF74; Cos52; ZNF520; Zfp520
External IDs OMIM194548 HomoloGene88675 GeneCards: ZNF74 Gene
RNA expression pattern
PBB GE ZNF74 205881 at tn.png
More reference expression data
Species Human Mouse
Entrez 7625 n/a
Ensembl ENSG00000185252 n/a
UniProt Q16587 n/a
RefSeq (mRNA) NM_003426 n/a
RefSeq (protein) NP_003417 n/a
Location (UCSC) Chr 22:
19.08 - 19.09 Mb
PubMed search [1] n/a

Zinc finger protein 74 is a protein that in humans is encoded by the ZNF74 gene.[1][2][3]



ZNF74 has been shown to interact with POLR2A.[4]


  1. ^ Aubry M, Marineau C, Zhang FR, Zahed L, Figlewicz D, Delattre O, Thomas G, de Jong PJ, Julien JP, Rouleau GA (Aug 1992). "Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2)". Genomics 13 (3): 641–8. PMID 1639391.  
  2. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.  
  3. ^ "Entrez Gene: ZNF74 zinc finger protein 74".  
  4. ^ Grondin, B; Côté F, Bazinet M, Vincent M, Aubry M (Oct. 1997). "Direct interaction of the KRAB/Cys2-His2 zinc finger protein ZNF74 with a hyperphosphorylated form of the RNA polymerase II largest subunit". J. Biol. Chem. (UNITED STATES) 272 (44): 27877–85. ISSN 0021-9258. PMID 9346935.  

Further reading

  • Aubry M, Demczuk S, Desmaze C, et al. (1994). "Isolation of a zinc finger gene consistently deleted in DiGeorge syndrome.". Hum. Mol. Genet. 2 (10): 1583–7. doi:10.1093/hmg/2.10.1583. PMID 8268910.  
  • Grondin B, Bazinet M, Aubry M (1996). "The KRAB zinc finger gene ZNF74 encodes an RNA-binding protein tightly associated with the nuclear matrix.". J. Biol. Chem. 271 (26): 15458–67. doi:10.1074/jbc.271.26.15458. PMID 8663113.  
  • Grondin B, Côté F, Bazinet M, et al. (1997). "Direct interaction of the KRAB/Cys2-His2 zinc finger protein ZNF74 with a hyperphosphorylated form of the RNA polymerase II largest subunit.". J. Biol. Chem. 272 (44): 27877–85. doi:10.1074/jbc.272.44.27877. PMID 9346935.  
  • Ravassard P, Côté F, Grondin B, et al. (2000). "ZNF74, a gene deleted in DiGeorge syndrome, is expressed in human neural crest-derived tissues and foregut endoderm epithelia.". Genomics 62 (1): 82–5. doi:10.1006/geno.1999.5982. PMID 10585771.  
  • Côté F, Boisvert FM, Grondin B, et al. (2001). "Alternative promoter usage and splicing of ZNF74 multifinger gene produce protein isoforms with a different repressor activity and nuclear partitioning.". DNA Cell Biol. 20 (3): 159–73. doi:10.1089/104454901300069004. PMID 11313019.  
  • Takase K, Ohtsuki T, Migita O, et al. (2001). "Association of ZNF74 gene genotypes with age-at-onset of schizophrenia.". Schizophrenia Research 52 (3): 161–5. doi:10.1016/S0920-9964(00)00191-2. PMID 11705709.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Germain-Desprez D, Bazinet M, Bouvier M, Aubry M (2003). "Oligomerization of transcriptional intermediary factor 1 regulators and interaction with ZNF74 nuclear matrix protein revealed by bioluminescence resonance energy transfer in living cells.". J. Biol. Chem. 278 (25): 22367–73. doi:10.1074/jbc.M302234200. PMID 12684500.  
  • Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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